WP4 Intervention & Product development

Intervention (in-vitro and in-vivo) & Product development

  • What's its about?
    In WP4, Shift2Health combines advanced laboratory research with practical food interventions to explore and counteract the effects of chronodisruption on obesity.
  • Intervention - in vitro
    • Identify novel biomarkers for obesity during chronodisruption
    Normal weight & obese enteroids:  
    • RNA sequencing
      • to study loss or shifts in the rhythmic gut transcriptome
    • Organ-on-a-chip based barrier integrity assays to determine
      • intestinal rhythmicity disruptions
      • identification of microbial metabolites
      • chronobiotics that affect rhythmicity in gut epithelial homeostasis during chronodisruption
  • Intervention - in vivo

    Food Intervention study in shift workers → See the graphic below for a visual summary.