WP2 Pre-Obesity Biomarkers

(Preclinical) pre-obesity biomarkers & biological pathways

  • What's its about?
    Exploring how night shift work may contribute to obesity through biological mechanisms. It focuses on key biomarkers linked to sleep, metabolism, and inflammation.

  • What is being measured?

    Biomarkers include...

    • Microbiome
    • Leaky gut markers
    • Chronotype
    • Sleep & appetite hormones
    • Metabolomics
    • Oxidative stress
    • Inflammation
    • Lipid/Glucose metabolism
  • What do we aim to find out?
    • Characterize biological mechanism of obesogenicity
    • Identifying early risk obesity markers
    • Acute and long-term effects of night shift
    • Characterize how circadian and sleep disruption link shift work to obesogenic biomarkers